• Excellence

  • Tenacious

  • Relentless

c1banpc-413.jpg c1banph-674.jpg

HEPDONE

HEPDONE

High-Throughput Evolution Platform for Discovery and Optimization of Novel Editors (HEPDONETM)

1.AI-Powered Discovery Platform using Metagenomics Data
c1_img01.svg
c1_img02.svg
c1_img03.svg
2.lterative High-Throughput Screening and Enzyme Engineering
c1_img04.svg
  • 50
    TB

    Base pairs

  • 311
    K

    Samples

  • 21
    B

    Proteins

  • 1
    M

    Cas

  • >
    100
    K

    CRISPR-Cas loci

Core Advantages of HEPDONETM

  • Al-assisted rational design

  • Random mutagenesis

  • The screening throughput reaches 10 billion+ per round，which can screen candidate editors with higher editing efficiency and different editing windows

  • “Eukaryotic-prokaryotic” shuttle screening, greatly improving validation efficiency

  • 2-3 rounds per week

c1_img05.svg

With our High-Throughput Direct Evolution Platform for Discovery and Optimization of Novel Editors (HEPDONE™), we have developed proprietary genome editing toolkits and multiple editing strategies, Our main focus has been on Base Editor that can insert, delete and replace DNA in highly precise manner ( to only edit intended DNA targets and avoid off-target editing) without causing a double-stranded break. Additionally, our guide RNA sequences can be designed to specifically target desired DNA or RNA sequences, reducing the risk of unintended changes to other genes and minimizing off-target effects.