PIPELINE

Metabolic Disease

Program

Indication

Target Gene

Discovery

Lead Optimization

IIT

Phase I/II

Phase III

Rights

YOLT-101
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Familial Hypercholesterolemia (FH)

PCSK9

Trial ID: NCT06461702 (Other Study ID Numbers: FH-YOLT-101-1)
Trial ID: NCT06458010 (Other Study ID Numbers: FH-YOLT-101-001)
YOLT-102
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ASCVD

Undisclosed
YOLT-103
Undisclosed

Undisclosed

Genetic Disease

Program

Indication

Target Gene

Discovery

Lead Optimization

IIT

Phase I/II

Phase III

Rights

YOLT-201
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Transthyretin Amyloidosis (ATTR)

TTR

Trial ID: NCT06082050 (Other Study ID Numbers: YOLT-201_2023_IIT_01)
Trial ID: NCT06539208 (Other Study ID Numbers: YT-YOLT-201-101)
YOLT-202
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Alpha-1 Antitrypsin Deficiency (AATD)

Undisclosed
YOLT-203
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Primary Hyperoxaluria (PH1)

HAO1

Trial ID: NCT06511349 (Other Study ID Numbers: PH1-YOLT-203-001)
YOLT-204
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Beta Thalassemia/Sickle Cell Disease

Undisclosed
YOLT-205
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Phenylketonuria (PKU)

Undisclosed
YOLT-206
Undisclosed

Undisclosed

Infectious Disease

Program

Indication

Target Gene

Discovery

Lead Optimization

IIT

Phase I/II

Phase III

Rights

YOLT-301
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Hepatitis B

Undisclosed
YOLT-302
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Undisclosed

Undisclosed

Metabolic Disease

Program

YOLT-101

Indication

Familial Hypercholesterolemia (FH)
Target Gene

PCSK9
Delivery

In vivo LNP

Discovery

Lead Optimization

IIT

Phase I/II

Trial ID: NCT06461702 (Other Study ID Numbers: FH-YOLT-101-1)

Trial ID: NCT06458010 (Other Study ID Numbers: FH-YOLT-101-001)

Program

YOLT-102

Indication

ASCVD
Target Gene

Undisclosed
Delivery

In vivo LNP

Discovery

Lead Optimization

IIT

Phase I/II

Program

YOLT-103

Indication

Undisclosed
Target Gene

Undisclosed
Delivery

In vivo LNP

Discovery

Lead Optimization

IIT

Phase I/II

Genetic Disease

Program

YOLT-201
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Indication

Transthyretin Amyloidosis (ATTR)
Target Gene

TTR
Delivery

In vivo LNP

Discovery

Lead Optimization

IIT

Phase I/II

Trial ID: NCT06082050 (Other Study ID Numbers: YOLT-201_2023_IIT_01)

Trial ID: NCT06539208 (Other Study ID Numbers: YT-YOLT-201-101)

Program

YOLT-202
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Indication

Alpha-1 Antitrypsin Deficiency (AATD)
Target Gene

Undisclosed
Delivery

In vivo LNP

Discovery

Lead Optimization

IIT

Phase I/II

Program

YOLT-203
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Indication

Primary Hyperoxaluria (PH1)
Target Gene

HAO1
Delivery

In vivo LNP

Discovery

Lead Optimization

IIT

Phase I/II

Trial ID: NCT06511349 (Other Study ID Numbers: PH1-YOLT-203-001)

Program

YOLT-204
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Indication

Beta Thalassemia/Sickle Cell Disease
Target Gene

Undisclosed
Delivery

In vivo LNP

Discovery

Lead Optimization

IIT

Phase I/II

Program

YOLT-205
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Indication

Phenylketonuria (PKU)
Target Gene

Undisclosed
Delivery

In vivo LNP

Discovery

Lead Optimization

IIT

Phase I/II

Program

YOLT-206

Indication

Undisclosed
Target Gene

Undisclosed
Delivery

In vivo LNP

Discovery

Lead Optimization

IIT

Phase I/II

Infectious Disease

Program

YOLT-301
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Indication

Hepatitis B
Target Gene

Undisclosed
Delivery

In vivo LNP

Discovery

Lead Optimization

IIT

Phase I/II

Program

YOLT-302
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Indication

Undisclosed
Target Gene

Undisclosed
Delivery

In vivo LNP

Discovery

Lead Optimization

IIT

Phase I/II