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PIPELINE

Genetic Disease

Program
Indication
Target Gene
Research
IIT Clinical
Phase I/II
Pivotal
Rights

Metabolic Disease

Program
Indication
Target Gene
Research
IIT Clinical
Phase I/II
Pivotal
Rights

Autoimmune Disease

Program
Indication
Target Gene
Research
IIT Clinical
Phase I/II
Pivotal
Rights

Genetic Disease

Program

YOLT-201
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  • Indication

    Transthyretin Amyloidosis (ATTR)

  • Target Gene

    TTR

  • Delivery

    Global

Research
Lead Optimization
IIT Clinical
Phase I/II
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Trial ID: NCT06082050 (Other Study ID Numbers: YOLT-201_2023_IIT_01)

Trial ID: NCT06539208 (Other Study ID Numbers: YT-YOLT-201-101)

Program

YOLT-202
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  • Indication

    Alpha-1 Antitrypsin Deficiency (AATD)

  • Target Gene

    SERPINA1

  • Delivery

    Global

Research
Lead Optimization
IIT Clinical
Phase I/II
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Program

YOLT-203
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  • Indication

    Primary Hyperoxaluria (PH1)

  • Target Gene

    HAO1

  • Delivery

    Global

Research
Lead Optimization
IIT Clinical
Phase I/II
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Trial ID: NCT06511349 (Other Study ID Numbers: PH1-YOLT-203-001)

Trial ID: NCT07587021 (Other Study ID Numbers: PH1-YOLT-203-2001) 

Program

YOLT-204
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  • Indication

    Beta Thalassemia/Sickle Cell Disease

  • Target Gene

    Undisclosed

  • Delivery

    Global

Research
Lead Optimization
IIT Clinical
Phase I/II
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Trial ID: NCT06678165 (Other Study ID Numbers: YOLT-204-IIT)

Program

YOLT-206

  • Indication

    Undisclosed

  • Target Gene

    Undisclosed

  • Delivery

    Global

Research
Lead Optimization
IIT Clinical
Phase I/II
demo

Metabolic Disease

Program

YOLT-101

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  • Indication

    Familial Hypercholesterolemia (FH)

  • Target Gene

    PCSK9

  • Delivery

    China: Salubris
    Ex-China: YolTech

Research
Lead Optimization
IIT Clinical
Phase I/II
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Trial ID: NCT06458010  (Other Study ID Numbers: FH-YOLT-101-001)

Program

YOLT-102

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  • Indication

    ASCVD

  • Target Gene

    LP(a)

  • Delivery

    Global

Research
Lead Optimization
IIT Clinical
Phase I/II
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Program

YOLT-103

  • Indication

    Undisclosed

  • Target Gene

    Undisclosed

  • Delivery

    Global

Research
Lead Optimization
IIT Clinical
Phase I/II
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Autoimmune Disease

Program

YOLT-401

  • Indication

    Autoimmune (in vivo CAR-T)

  • Target Gene

    Undisclosed

  • Delivery

    Global

Research
Lead Optimization
IIT Clinical
Phase I/II
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